Muscle, liver, and red blood cells
Move between skeletal muscle, liver, and a mitochondria-free red blood cell. Each tissue has its own pathways, controls, metabolites, and physiological role.
Explore Fluxion
Human metabolism, made interactive.
Run a coupled model of skeletal muscle, liver, red blood cells, and the shared bloodstream, then follow how cellular and whole-body conditions reshape metabolism in real time.
Multi-tissue simulation
Live pathway analysis
Guided experiments
01 · Whole-body metabolism
Follow metabolism across connected tissues
Fluxion couples three distinct tissue models through one shared bloodstream, making it possible to study how local cellular events become whole-body physiology.
Shared bloodstream
Watch glucose, lactate, oxygen, carbon dioxide, hormones, fatty acids, glycerol, alanine, and ketone bodies connect the modeled tissues.
Cross-tissue Overview
Compare each tissue's fuel, energy, membrane-potential, redox, and glutathione state beside a live blood ledger without switching away from the system-wide view.
Fed, fasting, and exercise states
Explore insulin and glucagon control, glycogen storage and release, glucose defense, muscle demand, fat mobilization, and ketone production.
Cori-cycle physiology
Follow lactate from working muscle into blood and through the liver's gluconeogenic pathway as glucose is rebuilt and returned to circulation.
Redox and oxidative stress
Investigate the pentose phosphate pathway, NADPH, glutathione, G6PD deficiency, favism, and why muscle retains defenses that mature red blood cells lack.
02 · System workflows
See the whole system, then compare what changed
The Body and Experiments tabs connect system-wide context with repeatable analysis, so a run can be understood at a glance and compared against other saved conditions.
Whole System
Body at a Glance
See skeletal muscle, liver, red blood cells, and the shared bloodstream in one live anatomical view. Tissue callouts surface key values while preserving the relationships between organs and circulation.
- Live tissue and bloodstream readouts
- Connected anatomical overview
- Direct access to tissue-specific detail
Experiments
Compare Saved Experiments
Overlay completed runs to see how changed inputs alter their trajectories and final results. The comparison workspace pairs the graph with input differences, outcome tables, and deterministic observations.
- Compare up to six saved runs
- Solid and dashed traces for rapid visual comparison
- Changed inputs, final results, and CSV export
03 · Simulation
Control the biological environment
Run repeatable experiments and watch tissues respond to changing energy demand, oxygen, substrates, hormones, enzyme activity, and scheduled interventions.
Core Simulation
Real-Time Metabolic Simulation
Run a continuously updating model of interconnected metabolic reactions and watch tissue-specific and shared-blood concentrations respond as the system changes.
- Live concentration updates
- Interconnected tissue and pathway behavior
- Adjustable simulation speed and controls
Experiment
Timed Velocity Changes
Schedule changes to reaction velocities at specific simulation times to model interventions, physiological events, or changing enzyme activity.
- Time-based reaction changes
- Repeatable experimental setups
- Before-and-after response analysis
Saved experiment library
Name, organize, favorite, duplicate, back up, import, and export completed simulation runs.
Side-by-side comparison
Overlay up to six saved experiments, inspect changed starting conditions and scheduled changes, compare final values, and export the comparison as CSV.
Expanded biochemical pathways
Explore glycolysis, glycogen metabolism, the TCA cycle, oxidative phosphorylation, gluconeogenesis, the complete pentose phosphate pathway, fat oxidation, and ketogenesis.
04 · Visualization & Analysis
Inspect metabolism from multiple perspectives
Move between individual metabolites, pathway-level flow, live graphs, and diagnostic data without losing sight of the larger system.
Explore
Interactive Metabolite Explorer
Select individual metabolites to examine their concentrations, production and consumption pathways, associated reactions, and changing behavior during a simulation.
- Metabolite-specific details
- Production and consumption tracking
- Reaction and enzyme relationships
Visualize
Live Reaction Flow Map
Follow metabolic activity across pathways through a visual map that updates reaction direction and relative flux as conditions change.
- Dynamic pathway activity
- Reaction direction and relative flux
- Connected pathway overview
Analyze
Diagnostics and Flux Analysis
Inspect reaction rates, pathway fluxes, balance checks, and system-wide diagnostics for a deeper look at how the simulation is behaving.
- Reaction-rate inspection
- Metabolic flux analysis
- Conservation and diagnostic checks
05 · Education
Turn observation into understanding
Structured activities connect visible simulation changes to the biological principles behind them.
Learn
Guided Educational Exercises
Use five structured exercises, condition presets, prompts, and live readouts to investigate respiration, enzyme deficiency, mitochondrial coupling, and tissue-specific redox defense.
- Oxygen supply and respiration
- Pyruvate kinase deficiency and mitochondrial uncoupling
- G6PD deficiency, favism, and the muscle NADPH backup
06 · Supporting Tools
Built for continued exploration
Supporting capabilities make the software easier to configure, interpret, maintain, and improve.
Adjustable Biological Conditions
Change oxygen availability, substrate supply, energy demand, and other modeled conditions to compare metabolic responses.
Live Concentration Graphs
Track selected metabolites over time and connect visible trends to the reactions and conditions driving them.
Automatic Updates
Receive new versions through the built-in update system as simulation behavior, educational content, and interface tools improve.
Integrated Release Notes
Review changes, fixes, and additions from within the software so each update is easy to understand.
Bug Reporting
Submit feedback and software issues through a dedicated reporting workflow that supports continued testing and refinement.
Searchable Help and Glossary
Open definitions and explanatory notes for metabolites, enzymes, kinetic parameters, interface controls, and modeled biological concepts.
Ready to explore?
See human metabolism in motion.
Download Fluxion and investigate cellular and cross-tissue metabolism through interactive simulation, visualization, and guided experimentation.